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James J Ley Selected Research

stilbazulenyl nitrone

1/2008Neuroprotective antioxidant STAZN protects against myocardial ischemia/reperfusion injury.
11/2007Neuroprotective effect of STAZN, a novel azulenyl nitrone antioxidant, in focal cerebral ischemia in rats: dose-response and therapeutic window.
6/2005Stilbazulenyl nitrone, a second-generation azulenyl nitrone antioxidant, confers enduring neuroprotection in experimental focal cerebral ischemia in the rat: neurobehavior, histopathology, and pharmacokinetics.
9/2003Stilbazulenyl nitrone, a novel antioxidant, is highly neuroprotective in focal ischemia.
6/2002Stilbazulenyl nitrone, a novel azulenyl nitrone antioxidant: improved neurological deficit and reduced contusion size after traumatic brain injury in rats.

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James J Ley Research Topics

Disease

4Brain Ischemia (Cerebral Ischemia)
01/2008 - 01/2005
3Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome)
11/2007 - 09/2003
2Ischemia
01/2008 - 09/2003
2Wounds and Injuries (Trauma)
06/2005 - 06/2002
1Coronary Occlusion
01/2008
1Reperfusion Injury
01/2008
1Myocardial Ischemia (Ischemic Heart Diseases)
01/2008
1Neurodegenerative Diseases (Neurodegenerative Disease)
01/2005
1Ischemic Stroke
09/2003
1Contusions
06/2002
1Traumatic Brain Injuries (Traumatic Brain Injury)
06/2002
1Stroke (Strokes)
05/2002

Drug/Important Bio-Agent (IBA)

7AntioxidantsIBA
01/2008 - 05/2002
5stilbazulenyl nitroneIBA
01/2008 - 06/2002
5azulenyl nitroneIBA
01/2008 - 06/2002
2Free RadicalsIBA
01/2005 - 05/2002
2Dimethyl Sulfoxide (DMSO)FDA LinkGeneric
09/2003 - 06/2002
1Cardiotonic Agents (Cardiac Stimulants)IBA
01/2008
1Free Radical ScavengersIBA
01/2008
1Neuroprotective AgentsIBA
11/2007
1nitronesIBA
01/2005
1Pharmaceutical PreparationsIBA
05/2002
1cumene (cumol)IBA
05/2002
1disufenton sodium (NXY 059)IBA
05/2002

Therapy/Procedure

3Sutures (Suture)
11/2007 - 09/2003
1Therapeutics
06/2002